Compound Detail
CHEMBL2047250
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Basic Information
| ChEMBL ID | CHEMBL2047250 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LREDHDABOIKCQR-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
342.3
MW (Da)
4.39
ALogP
4
HBA
2
HBD
63.8
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.09 | 5.09 | 8100.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 4.64 | 4.64 | 23100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 8100.0 | nM | 5.09 | Antiangiogenic activity in VEGF/bFGF-stimulated chicken embryo after 48 hrs by C... | 22739090 |
| Platelet-derived growth factor receptor beta | IC50 | = | 23100.0 | nM | 4.64 | Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured aft... | 22739090 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22739090 | 10.1016/j.bmc.2012.05.068 | NON-PROTEIN TARGET | 1 |
| 22739090 | 10.1016/j.bmc.2012.05.068 | A-431 | 1 |
| 22739090 | 10.1016/j.bmc.2012.05.068 | Platelet-derived growth factor receptor beta | 1 |
| 22739090 | 10.1016/j.bmc.2012.05.068 | Vascular endothelial growth factor receptor 2 | 1 |
| 22739090 | 10.1016/j.bmc.2012.05.068 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine