Assay Detail
Functional
CHEMBL2050150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiangiogenic activity in VEGF/bFGF-stimulated chicken embryo after 48 hrs by CAM assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gallus gallus |
| Tissue | Embryo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.13 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.40 |
| CHEMBL2047247 | — | — | 1 | 6.09 |
| CHEMBL2047244 | — | — | 1 | 5.67 |
| CHEMBL2047253 | — | — | 1 | 5.43 |
| CHEMBL2047250 | — | — | 1 | 5.09 |
| CHEMBL2047245 | — | — | 1 | 4.83 |
| CHEMBL2047249 | — | — | 1 | 4.72 |
| CHEMBL2047251 | — | — | 1 | 4.44 |
| CHEMBL2047241 | — | — | 1 | 4.33 |
| CHEMBL2047243 | — | — | 1 | 4.29 |
| CHEMBL2047246 | — | — | 1 | 4.11 |
| CHEMBL2047252 | — | — | 1 | - |
| CHEMBL2047248 | — | — | 1 | - |
| CHEMBL2047242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2047247 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL2047244 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2047253 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL2047250 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2047245 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL2047249 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL2047251 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL2047241 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL2047243 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL2047246 | — | IC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL2047252 | — | IC50 | - | — | - | |
| CHEMBL2047248 | — | IC50 | = | 104300.0 | nM | - |
| CHEMBL2047242 | — | IC50 | - | — | - |