Assay Detail
Functional
CHEMBL2050149
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Antiproliferative activity against human A431 cells after 48 hrs by CYQUANT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.92 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047243 | — | — | 1 | 5.31 |
| CHEMBL2047253 | — | — | 1 | 5.01 |
| CHEMBL2047247 | — | — | 1 | 5.01 |
| CHEMBL2047246 | — | — | 1 | 5.01 |
| CHEMBL2047251 | — | — | 1 | 4.86 |
| CHEMBL2047241 | — | — | 1 | 4.30 |
| CHEMBL2047252 | — | — | 1 | - |
| CHEMBL2047250 | — | — | 1 | - |
| CHEMBL2047249 | — | — | 1 | - |
| CHEMBL2047248 | — | — | 1 | - |
| CHEMBL2047242 | — | — | 1 | - |
| CHEMBL2047245 | — | — | 1 | - |
| CHEMBL2047244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047243 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2047253 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2047247 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2047246 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2047251 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL2047241 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL2047252 | — | IC50 | = | 158100.0 | nM | - |
| CHEMBL2047250 | — | IC50 | = | 306300.0 | nM | - |
| CHEMBL2047249 | — | IC50 | = | 103100.0 | nM | - |
| CHEMBL2047248 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2047242 | — | IC50 | = | 235000.0 | nM | - |
| CHEMBL2047245 | — | IC50 | = | 126400.0 | nM | - |
| CHEMBL2047244 | — | IC50 | = | 126400.0 | nM | - |