Assay Detail
Binding
CHEMBL2050776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]serotonin uptake at human SERT expressed in CHO cells after 10 min by scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.45 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047570 | — | — | 1 | 6.77 |
| CHEMBL2047561 | — | — | 1 | 6.59 |
| CHEMBL2047571 | — | — | 1 | 6.58 |
| CHEMBL2047573 | — | — | 1 | 6.47 |
| CHEMBL2047578 | — | — | 1 | 6.45 |
| CHEMBL2047580 | — | — | 1 | 6.43 |
| CHEMBL1818442 | AMITIFADINE HYDROCHLORIDE | 2.0 | 1 | 6.39 |
| CHEMBL2047574 | — | — | 1 | 6.37 |
| CHEMBL2047572 | — | — | 1 | 6.37 |
| CHEMBL2047569 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047570 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL2047561 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL2047571 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL2047573 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL2047578 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL2047580 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL1818442 | AMITIFADINE HYDROCHLORIDE | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL2047574 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL2047572 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL2047569 | — | IC50 | = | 768.0 | nM | 6.12 |