Assay Detail
Binding
CHEMBL2051428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.60 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215669 | — | — | 1 | 9.37 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.66 |
| CHEMBL3216999 | — | — | 1 | 8.27 |
| CHEMBL3215668 | — | — | 1 | 8.12 |
| CHEMBL3217001 | — | — | 1 | 8.11 |
| CHEMBL3217210 | — | — | 1 | 7.92 |
| CHEMBL3215667 | — | — | 1 | 7.57 |
| CHEMBL3216560 | — | — | 1 | 7.38 |
| CHEMBL3217211 | — | — | 1 | 7.32 |
| CHEMBL3217000 | — | — | 1 | 6.96 |
| CHEMBL1201776 | TAPENTADOL | 4.0 | 1 | 6.80 |
| CHEMBL3216780 | — | — | 1 | 6.77 |
| CHEMBL3215885 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215669 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL70 | MORPHINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL3216999 | — | Ki | = | 5.41 | nM | 8.27 |
| CHEMBL3215668 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL3217001 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3217210 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3215667 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3216560 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3217211 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL3217000 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1201776 | TAPENTADOL | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3216780 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3215885 | — | Ki | = | 2900.0 | nM | 5.54 |