Assay Detail
Functional
CHEMBL2060190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured every 1.5 secs for 60 secs by Fluo-4-AM based fluorometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 4 (CHEMBL2787) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.51 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.89 |
| CHEMBL2058378 | — | — | 1 | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.54 |
| CHEMBL2058382 | — | — | 1 | 4.56 |
| CHEMBL2058381 | — | — | 1 | 4.07 |
| CHEMBL2058379 | — | — | 1 | - |
| CHEMBL2058380 | — | — | 1 | - |
| CHEMBL2058383 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2058378 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL2058382 | — | EC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL2058381 | — | EC50 | = | 85600.0 | nM | 4.07 |
| CHEMBL2058379 | — | EC50 | = | 609000.0 | nM | - |
| CHEMBL2058380 | — | EC50 | = | 465000.0 | nM | - |
| CHEMBL2058383 | — | EC50 | = | 1400000.0 | nM | - |