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Assay Detail

CHEMBL2061583

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Autocuration

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety.
Animati F, Berettoni M, Bigioni M, Binaschi M, Cipollone A, Irrissuto C, Nardelli F, Olivieri L.
Bioorg Med Chem Lett (2012) 22 : 5013 -5017
PubMed 22749423 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.86 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2057482 1 9.15
CHEMBL2057484 1 8.77
CHEMBL435191 EDOTECARIN 3.0 1 8.19
CHEMBL65 CAMPTOTHECIN -1.0 1 8.15
CHEMBL2057488 1 7.93
CHEMBL2057481 1 7.90
CHEMBL2057483 1 7.27
CHEMBL2057487 1 7.26
CHEMBL2057485 1 7.05
CHEMBL2057486 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2057482 IC50 = 0.7 nM 9.15
CHEMBL2057484 IC50 = 1.7 nM 8.77
CHEMBL435191 EDOTECARIN IC50 = 6.5 nM 8.19
CHEMBL65 CAMPTOTHECIN IC50 = 7.0 nM 8.15
CHEMBL2057488 IC50 = 11.7 nM 7.93
CHEMBL2057481 IC50 = 12.7 nM 7.90
CHEMBL2057483 IC50 = 54.0 nM 7.27
CHEMBL2057487 IC50 = 55.0 nM 7.26
CHEMBL2057485 IC50 = 90.0 nM 7.05
CHEMBL2057486 IC50 = 127.0 nM 6.90