Assay Detail
ADMET
CHEMBL2061657
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Inhibition of CYP2C9
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.40 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059521 | — | — | 1 | 5.80 |
| CHEMBL2059520 | — | — | 1 | 5.40 |
| CHEMBL2059527 | — | — | 1 | 5.40 |
| CHEMBL2059517 | — | — | 1 | 5.30 |
| CHEMBL2059519 | — | — | 1 | 5.10 |
| CHEMBL2059515 | — | — | 1 | - |
| CHEMBL2059516 | — | — | 1 | - |
| CHEMBL2057282 | — | — | 1 | - |
| CHEMBL2057285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059521 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL2059520 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2059527 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2059517 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2059519 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2059515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2059516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2057282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2057285 | — | IC50 | > | 10000.0 | nM | - |