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Assay Detail

CHEMBL2061832

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Binding
Inhibition of Toxoplasma gondii CDPK1
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Toxoplasma gondii
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calmodulin-domain protein kinase 1 (CHEMBL1781862)
Type SINGLE PROTEIN
Organism Toxoplasma gondii

Publication

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E.
Bioorg Med Chem Lett (2012) 22 : 5264 -5267
PubMed 22795629 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.93 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2030561 1 7.82
CHEMBL2059171 1 7.75
CHEMBL2059176 1 7.70
CHEMBL2059168 1 7.66
CHEMBL2059353 1 7.54
CHEMBL2059177 1 7.52
CHEMBL2059170 1 7.39
CHEMBL2059361 1 7.37
CHEMBL2059169 1 7.22
CHEMBL2059358 1 7.20
CHEMBL2059355 1 7.19
CHEMBL2059357 1 7.17
CHEMBL2059354 1 7.17
CHEMBL2059167 1 7.16
CHEMBL2059356 1 6.92
CHEMBL2059165 1 6.92
CHEMBL2059164 1 6.89
CHEMBL170250 1 6.89
CHEMBL2059174 1 6.85
CHEMBL2059162 1 6.85
CHEMBL2059175 1 6.82
CHEMBL2059172 1 6.80
CHEMBL2059359 1 6.80
CHEMBL2059166 1 6.75
CHEMBL2059362 1 6.75
CHEMBL2059363 1 6.72
CHEMBL2059360 1 6.66
CHEMBL2030560 1 6.64
CHEMBL2059364 1 6.58
CHEMBL2059163 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2030561 IC50 = 15.0 nM 7.82
CHEMBL2059171 IC50 = 18.0 nM 7.75
CHEMBL2059176 IC50 = 20.0 nM 7.70
CHEMBL2059168 IC50 = 22.0 nM 7.66
CHEMBL2059353 IC50 = 29.0 nM 7.54
CHEMBL2059177 IC50 = 30.0 nM 7.52
CHEMBL2059170 IC50 = 41.0 nM 7.39
CHEMBL2059361 IC50 = 43.0 nM 7.37
CHEMBL2059169 IC50 = 60.0 nM 7.22
CHEMBL2059358 IC50 = 63.0 nM 7.20
CHEMBL2059355 IC50 = 65.0 nM 7.19
CHEMBL2059357 IC50 = 67.0 nM 7.17
CHEMBL2059354 IC50 = 68.0 nM 7.17
CHEMBL2059167 IC50 = 69.0 nM 7.16
CHEMBL2059165 IC50 = 120.0 nM 6.92
CHEMBL2059356 IC50 = 120.0 nM 6.92
CHEMBL2059164 IC50 = 130.0 nM 6.89
CHEMBL170250 IC50 = 130.0 nM 6.89
CHEMBL2059162 IC50 = 140.0 nM 6.85
CHEMBL2059174 IC50 = 140.0 nM 6.85
CHEMBL2059175 IC50 = 150.0 nM 6.82
CHEMBL2059172 IC50 = 160.0 nM 6.80
CHEMBL2059359 IC50 = 160.0 nM 6.80
CHEMBL2059166 IC50 = 180.0 nM 6.75
CHEMBL2059362 IC50 = 180.0 nM 6.75
CHEMBL2059363 IC50 = 190.0 nM 6.72
CHEMBL2059360 IC50 = 220.0 nM 6.66
CHEMBL2030560 IC50 = 230.0 nM 6.64
CHEMBL2059364 IC50 = 260.0 nM 6.58
CHEMBL2059163 IC50 = 380.0 nM 6.42
CHEMBL2059179 IC50 = 410.0 nM 6.39
CHEMBL2059173 IC50 = 520.0 nM 6.28
CHEMBL2059365 IC50 = 570.0 nM 6.24
CHEMBL2059352 IC50 = 660.0 nM 6.18
CHEMBL685 MEBENDAZOLE IC50 = 670.0 nM 6.17
CHEMBL2059178 IC50 = 1000.0 nM 6.00
CHEMBL2059161 IC50 > 3000.0 nM -
CHEMBL2059160 IC50 > 3000.0 nM -
CHEMBL2059159 IC50 > 3000.0 nM -