Compound Detail
CHEMBL2059354
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Basic Information
| ChEMBL ID | CHEMBL2059354 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SHHUNSGOJUDPIE-KRWDZBQOSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
348.4
MW (Da)
3.33
ALogP
5
HBA
1
HBD
64.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calmodulin-domain protein kinase 1 CHEMBL1781862 | IC50 | 7.17 | 7.17 | 68.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.15 | 7.15 | 71.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calmodulin-domain protein kinase 1 | IC50 | = | 68.0 | nM | 7.17 | Inhibition of Toxoplasma gondii CDPK1 | 22795629 |
| Unchecked | IC50 | = | 71.0 | nM | 7.15 | Inhibition of Cryptosporidium parvum CDPK1 | 22795629 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22795629 | 10.1016/j.bmcl.2012.06.050 | Calmodulin-domain protein kinase 1 | 1 |
| 22795629 | 10.1016/j.bmcl.2012.06.050 | Unchecked | 1 |
| 22795629 | 10.1016/j.bmcl.2012.06.050 | Toxoplasma gondii | 1 |
| 22795629 | 10.1016/j.bmcl.2012.06.050 | Cryptosporidium parvum | 1 |
| 22795629 | 10.1016/j.bmcl.2012.06.050 | HL-60 | 1 |
| 22795629 | 10.1016/j.bmcl.2012.06.050 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine