Assay Detail
Binding
CHEMBL2065090
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Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21-DE3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of α-synuclein ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.05 | 7.49 |
| IC50 | 19 | 5.54 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063787 | — | — | 2 | 7.49 |
| CHEMBL2063797 | — | — | 2 | 7.31 |
| CHEMBL2063798 | — | — | 2 | 7.24 |
| CHEMBL2063788 | — | — | 2 | 7.12 |
| CHEMBL2063789 | — | — | 2 | 6.97 |
| CHEMBL1976750 | — | — | 2 | 6.93 |
| CHEMBL2063785 | — | — | 2 | 6.91 |
| CHEMBL2063786 | — | — | 2 | 6.46 |
| CHEMBL2062539 | — | — | 2 | 5.64 |
| CHEMBL2063792 | — | — | 2 | 5.48 |
| CHEMBL2063791 | — | — | 2 | 5.41 |
| CHEMBL2063793 | — | — | 2 | 4.97 |
| CHEMBL2063794 | — | — | 2 | 4.85 |
| CHEMBL3142202 | — | — | 2 | 4.80 |
| CHEMBL2063795 | — | — | 2 | 4.63 |
| CHEMBL1629795 | — | — | 2 | 4.58 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 2 | 4.58 |
| CHEMBL2063796 | — | — | 2 | 4.49 |
| CHEMBL2063790 | — | — | 2 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063787 | — | Ki | = | 32.1 | nM | 7.49 |
| CHEMBL2063797 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2063798 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL2063788 | — | Ki | = | 75.3 | nM | 7.12 |
| CHEMBL2063789 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL1976750 | — | Ki | = | 116.5 | nM | 6.93 |
| CHEMBL2063785 | — | Ki | = | 121.8 | nM | 6.91 |
| CHEMBL2063787 | — | IC50 | = | 133.7 | nM | 6.87 |
| CHEMBL2063797 | — | IC50 | = | 203.9 | nM | 6.69 |
| CHEMBL2063798 | — | IC50 | = | 241.3 | nM | 6.62 |
| CHEMBL2063788 | — | IC50 | = | 313.8 | nM | 6.50 |
| CHEMBL2063786 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL2063789 | — | IC50 | = | 441.5 | nM | 6.36 |
| CHEMBL1976750 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL2063785 | — | IC50 | = | 507.1 | nM | 6.29 |
| CHEMBL2063786 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL2062539 | — | IC50 | = | 2286.0 | nM | 5.64 |
| CHEMBL2063792 | — | IC50 | = | 3329.0 | nM | 5.48 |
| CHEMBL2063791 | — | IC50 | = | 3928.0 | nM | 5.41 |
| CHEMBL2063793 | — | IC50 | = | 10736.0 | nM | 4.97 |
| CHEMBL2063794 | — | IC50 | = | 14031.0 | nM | 4.85 |
| CHEMBL3142202 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2063795 | — | IC50 | = | 23491.0 | nM | 4.63 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1629795 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2063796 | — | IC50 | = | 32074.0 | nM | 4.49 |
| CHEMBL2063790 | — | IC50 | = | 37327.0 | nM | 4.43 |
| CHEMBL1629795 | — | Ki | > | 500.0 | nM | - |
| CHEMBL3142202 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063790 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063791 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063792 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063793 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063794 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063795 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2063796 | — | Ki | > | 500.0 | nM | - |
| CHEMBL2062539 | — | Ki | > | 500.0 | nM | - |
| CHEMBL828 | PHENOTHIAZINE | Ki | > | 500.0 | nM | - |