Assay Detail
Binding
CHEMBL2065481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL2125) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.87 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064616 | — | — | 1 | 8.03 |
| CHEMBL2064615 | — | — | 1 | 7.54 |
| CHEMBL20943 | — | — | 1 | 7.48 |
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 6.24 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 5.99 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 5.95 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | - |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | - |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064616 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL2064615 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL20943 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | Ki | = | 581.7 | nM | 6.24 |
| CHEMBL267930 | SPIPERONE | Ki | = | 1033.0 | nM | 5.99 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 1134.0 | nM | 5.95 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | > | 10000.0 | nM | - |
| CHEMBL51 | KETANSERIN | Ki | > | 10000.0 | nM | - |
| CHEMBL1437 | NOREPINEPHRINE | Ki | > | 10000.0 | nM | - |