Assay Detail
Functional
CHEMBL2065510
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Inhibition of TNFalpha-induced necroptosis in FEDD-deficient human Jurkat T cells after 24 hrs by ATP-based viability assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.11 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064693 | — | — | 1 | 7.05 |
| CHEMBL223735 | — | — | 1 | 6.80 |
| CHEMBL374761 | — | — | 1 | 6.55 |
| CHEMBL2064694 | — | — | 1 | 6.55 |
| CHEMBL374521 | — | — | 1 | 6.54 |
| CHEMBL2064695 | — | — | 1 | 6.48 |
| CHEMBL222786 | — | — | 1 | 6.41 |
| CHEMBL387398 | — | — | 1 | 6.34 |
| CHEMBL2064698 | — | — | 1 | 6.21 |
| CHEMBL2064696 | — | — | 1 | 6.19 |
| CHEMBL221781 | — | — | 1 | 6.12 |
| CHEMBL390560 | — | — | 1 | 4.92 |
| CHEMBL2064691 | — | — | 1 | 4.82 |
| CHEMBL2064697 | — | — | 1 | 4.57 |
| CHEMBL2064690 | — | — | 1 | - |
| CHEMBL2064692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064693 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL223735 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL374761 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2064694 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL374521 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2064695 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL222786 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL387398 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2064698 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2064696 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL221781 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL390560 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2064691 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2064697 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2064690 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2064692 | — | EC50 | > | 100000.0 | nM | - |