Assay Detail
Functional
CHEMBL2066971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against thymidine kinase positive VZV OKa infected in HEL cells by plaque formation assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human herpesvirus 3 strain Oka vaccine |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.02 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063192 | — | — | 1 | 8.70 |
| CHEMBL2063194 | — | — | 1 | 8.15 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.00 |
| CHEMBL2063195 | — | — | 1 | 7.00 |
| CHEMBL2063188 | — | — | 1 | 6.85 |
| CHEMBL419692 | — | — | 1 | 6.25 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.79 |
| CHEMBL2063190 | — | — | 1 | 5.41 |
| CHEMBL2063185 | — | — | 1 | - |
| CHEMBL2063186 | — | — | 1 | - |
| CHEMBL2063187 | — | — | 1 | - |
| CHEMBL2063189 | — | — | 1 | - |
| CHEMBL2063191 | — | — | 1 | - |
| CHEMBL2063193 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063192 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2063194 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2063195 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2063188 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL419692 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL2063190 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2063185 | — | EC50 | > | 23400.0 | nM | - |
| CHEMBL2063186 | — | EC50 | > | 23000.0 | nM | - |
| CHEMBL2063187 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL2063189 | — | EC50 | > | 23000.0 | nM | - |
| CHEMBL2063191 | — | EC50 | > | 6800.0 | nM | - |
| CHEMBL2063193 | — | EC50 | > | 1400.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL5314375 | CIDOFOVIR | EC50 | - | — | - |