Assay Detail
Functional
CHEMBL2066972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against thymidine kinase negative VZV 07/01 infected in HEL cells by plaque formation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.41 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063192 | — | — | 1 | 8.77 |
| CHEMBL2063194 | — | — | 1 | 8.30 |
| CHEMBL419692 | — | — | 1 | 6.68 |
| CHEMBL2063195 | — | — | 1 | 6.64 |
| CHEMBL2063188 | — | — | 1 | 6.52 |
| CHEMBL2063190 | — | — | 1 | 5.85 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.28 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.27 |
| CHEMBL2063185 | — | — | 1 | - |
| CHEMBL2063186 | — | — | 1 | - |
| CHEMBL2063187 | — | — | 1 | - |
| CHEMBL2063189 | — | — | 1 | - |
| CHEMBL2063193 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063192 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2063194 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL419692 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2063195 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2063188 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2063190 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2063185 | — | EC50 | > | 23400.0 | nM | - |
| CHEMBL2063186 | — | EC50 | > | 23000.0 | nM | - |
| CHEMBL2063187 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL2063189 | — | EC50 | > | 4600.0 | nM | - |
| CHEMBL2063193 | — | EC50 | > | 1400.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL5314375 | CIDOFOVIR | EC50 | - | — | - |