Assay Detail
Functional
CHEMBL2066980
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Antiviral activity against Vaccinia virus Lederie infected in HEL cells by viral CPE assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.83 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063192 | — | — | 1 | 7.96 |
| CHEMBL2063194 | — | — | 1 | 6.89 |
| CHEMBL2063195 | — | — | 1 | 6.00 |
| CHEMBL419692 | — | — | 1 | 5.96 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.85 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.82 |
| CHEMBL2063190 | — | — | 1 | 4.35 |
| CHEMBL2063185 | — | — | 1 | - |
| CHEMBL2063186 | — | — | 1 | - |
| CHEMBL2063187 | — | — | 1 | - |
| CHEMBL2063188 | — | — | 1 | - |
| CHEMBL2063189 | — | — | 1 | - |
| CHEMBL2063191 | — | — | 1 | - |
| CHEMBL2063193 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063192 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2063194 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2063195 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL419692 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2063190 | — | EC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL2063185 | — | EC50 | > | 117000.0 | nM | - |
| CHEMBL2063186 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063187 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL2063188 | — | EC50 | >= | 34000.0 | nM | - |
| CHEMBL2063189 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063191 | — | EC50 | > | 6800.0 | nM | - |
| CHEMBL2063193 | — | EC50 | > | 7000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | > | 1000000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | >= | 93000.0 | nM | - |