Assay Detail
Binding
CHEMBL2071936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay
64
Total Activities
64
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily KQT member 1 (CHEMBL1866) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 5.76 | 6.58 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2070953 | — | — | 1 | 6.58 |
| CHEMBL2070970 | — | — | 1 | 6.38 |
| CHEMBL2070988 | — | — | 1 | 6.22 |
| CHEMBL2070954 | — | — | 1 | 6.16 |
| CHEMBL2070968 | — | — | 1 | 6.14 |
| CHEMBL2070962 | — | — | 1 | 6.11 |
| CHEMBL2070961 | — | — | 1 | 6.09 |
| CHEMBL2070964 | — | — | 1 | 6.06 |
| CHEMBL2070952 | — | — | 1 | 6.05 |
| CHEMBL2070958 | — | — | 1 | 6.00 |
| CHEMBL2070967 | — | — | 1 | 5.99 |
| CHEMBL2070966 | — | — | 1 | 5.94 |
| CHEMBL2071004 | — | — | 1 | 5.88 |
| CHEMBL2070978 | — | — | 1 | 5.87 |
| CHEMBL2070832 | — | — | 1 | 5.86 |
| CHEMBL2070969 | — | — | 1 | 5.85 |
| CHEMBL2070830 | — | — | 1 | 5.83 |
| CHEMBL2070965 | — | — | 1 | 5.79 |
| CHEMBL2070959 | — | — | 1 | 5.77 |
| CHEMBL1352968 | — | — | 1 | 5.77 |
| CHEMBL2070960 | — | — | 1 | 5.75 |
| CHEMBL2070955 | — | — | 1 | 5.59 |
| CHEMBL2070985 | — | — | 1 | 5.54 |
| CHEMBL2070987 | — | — | 1 | 5.36 |
| CHEMBL2070957 | — | — | 1 | 5.32 |
| CHEMBL2070981 | — | — | 1 | 5.21 |
| CHEMBL2070977 | — | — | 1 | 5.10 |
| CHEMBL2070982 | — | — | 1 | 5.09 |
| CHEMBL2070995 | — | — | 1 | 4.89 |
| CHEMBL2071006 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2070953 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2070970 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2070988 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2070954 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2070968 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2070962 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2070961 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2070964 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL2070952 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2070958 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2070967 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2070966 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL2071004 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2070978 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL2070832 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL2070969 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2070830 | — | EC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL2070965 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL2070959 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL1352968 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL2070960 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2070955 | — | EC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL2070985 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL2070987 | — | EC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL2070957 | — | EC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL2070981 | — | EC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL2070977 | — | EC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL2070982 | — | EC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL2070995 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2071006 | — | EC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL2070971 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070963 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070956 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070831 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070979 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071009 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071010 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071008 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071007 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071005 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071003 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071001 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071000 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070999 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070994 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070996 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070997 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071002 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2070998 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2071011 | — | Activity | - | — | - |