Assay Detail
Binding
CHEMBL2072352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate addition
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.11 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.92 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.00 |
| CHEMBL2071425 | DIACETYLGERANYLPHENAZINEDIOL | — | 1 | 5.70 |
| CHEMBL2071424 | GERANYLPHENAZINEDIOL | — | 1 | 5.58 |
| CHEMBL2071426 | — | — | 1 | 5.34 |
| CHEMBL2071427 | — | — | 1 | - |
| CHEMBL463686 | PHENAZINE-1-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL2071428 | ENDOPHENAZINE A | — | 1 | - |
| CHEMBL1952289 | ENDOPHENAZINE B | — | 1 | - |
| CHEMBL130 | CHLORAMPHENICOL | 4.0 | 1 | - |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2071425 | DIACETYLGERANYLPHENAZINEDIOL | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL2071424 | GERANYLPHENAZINEDIOL | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL2071426 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL2071427 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL463686 | PHENAZINE-1-CARBOXYLIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL2071428 | ENDOPHENAZINE A | IC50 | > | 50000.0 | nM | - |
| CHEMBL1952289 | ENDOPHENAZINE B | IC50 | > | 50000.0 | nM | - |
| CHEMBL130 | CHLORAMPHENICOL | IC50 | - | — | - | |
| CHEMBL83 | TAMOXIFEN | IC50 | - | — | - |