Assay Detail
Functional
CHEMBL2072687
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in absence of tetracycline after 3 days
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.92 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.47 |
| CHEMBL2070544 | — | — | 1 | 7.30 |
| CHEMBL2070695 | — | — | 1 | 7.16 |
| CHEMBL2070534 | — | — | 1 | 7.05 |
| CHEMBL2070537 | — | — | 1 | 7.00 |
| CHEMBL2070535 | — | — | 1 | 6.89 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.89 |
| CHEMBL2070681 | — | — | 1 | 6.75 |
| CHEMBL2070694 | — | — | 1 | 6.64 |
| CHEMBL2070689 | — | — | 1 | 6.62 |
| CHEMBL2070684 | — | — | 1 | 6.60 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.66 |
| CHEMBL2070538 | — | — | 1 | - |
| CHEMBL2070696 | — | — | 1 | - |
| CHEMBL2070539 | — | — | 1 | - |
| CHEMBL2070540 | — | — | 1 | - |
| CHEMBL2070541 | — | — | 1 | - |
| CHEMBL2070688 | — | — | 1 | - |
| CHEMBL2070687 | — | — | 1 | - |
| CHEMBL2070686 | — | — | 1 | - |
| CHEMBL2070542 | — | — | 1 | - |
| CHEMBL2070683 | — | — | 1 | - |
| CHEMBL2070543 | — | — | 1 | - |
| CHEMBL2070677 | — | — | 1 | - |
| CHEMBL2070676 | — | — | 1 | - |
| CHEMBL1462697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2070544 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2070695 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2070534 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2070537 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2070535 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2070681 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2070694 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2070689 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2070684 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2070538 | — | IC50 | - | — | - | |
| CHEMBL2070696 | — | IC50 | - | — | - | |
| CHEMBL2070539 | — | IC50 | - | — | - | |
| CHEMBL2070540 | — | IC50 | - | — | - | |
| CHEMBL2070541 | — | IC50 | - | — | - | |
| CHEMBL2070688 | — | IC50 | - | — | - | |
| CHEMBL2070687 | — | IC50 | - | — | - | |
| CHEMBL2070686 | — | IC50 | - | — | - | |
| CHEMBL2070542 | — | IC50 | - | — | - | |
| CHEMBL2070683 | — | IC50 | - | — | - | |
| CHEMBL2070543 | — | IC50 | - | — | - | |
| CHEMBL2070677 | — | IC50 | - | — | - | |
| CHEMBL2070676 | — | IC50 | - | — | - | |
| CHEMBL1462697 | — | IC50 | - | — | - |