Assay Detail
Functional
CHEMBL2076246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.12 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074851 | Cyanine-863 | — | 1 | 6.29 |
| CHEMBL170 | QUININE | 4.0 | 1 | 5.39 |
| CHEMBL2074659 | MEPIPERPHENIDOL BROMIDE | -1.0 | 1 | 5.15 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | — | 1 | 4.95 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.90 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 4.76 |
| CHEMBL2074647 | METIPRENALINE | 2.0 | 1 | 4.43 |
| CHEMBL463 | AMINOHIPPURIC ACID | 4.0 | 1 | - |
| CHEMBL110739 | CORTICOSTERONE | 3.0 | 1 | - |
| CHEMBL897 | PROBENECID | 4.0 | 1 | - |
| CHEMBL821 | GUANIDINE | 4.0 | 1 | - |
| CHEMBL1686 | ALPHA-KETOGLUTARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074851 | Cyanine-863 | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL170 | QUININE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2074659 | MEPIPERPHENIDOL BROMIDE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL2074647 | METIPRENALINE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL463 | AMINOHIPPURIC ACID | IC50 | = | 1300000.0 | nM | - |
| CHEMBL110739 | CORTICOSTERONE | IC50 | = | 151000.0 | nM | - |
| CHEMBL897 | PROBENECID | IC50 | = | 1640000.0 | nM | - |
| CHEMBL821 | GUANIDINE | IC50 | = | 4470000.0 | nM | - |
| CHEMBL1686 | ALPHA-KETOGLUTARIC ACID | IC50 | = | 740000.0 | nM | - |