Compound Detail
CHEMBL2074659
MEPIPERPHENIDOL BROMIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2074659 |
| Name | MEPIPERPHENIDOL BROMIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CALMOSBYAPVNLT-UHFFFAOYSA-M |
| Parent Compound | CHEMBL2078910 |
| Active Moiety | CHEMBL2078910 |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
3
Known Names
Molecular Properties
290.5
MW (Da)
3.81
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.79
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 2 meas. best 5.15
Ki 2 meas. best 5.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 2 CHEMBL1743122 | Ki | 5.32 | 5.32 | 4800.0 | 1 |
| Solute carrier family 22 member 1 CHEMBL2073670 | Ki | 5.28 | 5.28 | 5200.0 | 1 |
| Solute carrier family 22 member 1 CHEMBL2073670 | IC50 | 5.15 | 5.15 | 7100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 2 | Ki | = | 4800.0 | nM | 5.32 | TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes | 9260930 |
| Solute carrier family 22 member 1 | Ki | = | 5200.0 | nM | 5.28 | TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes | 7990927 |
| Solute carrier family 22 member 1 | IC50 | = | 7100.0 | nM | 5.15 | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes | 11502595 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11502595 | 10.1152/ajprenal.2001.281.3.f454 | Solute carrier family 22 member 2 | 1 |
| 11502595 | 10.1152/ajprenal.2001.281.3.f454 | Solute carrier family 22 member 1 | 1 |
| 9260930 | 10.1089/dna.1997.16.871 | Solute carrier family 22 member 2 | 1 |
| 7990927 | 10.1038/372549a0 | Solute carrier family 22 member 1 | 1 |
Data from ChEMBL 36 via Core Engine