Assay Detail
Functional
CHEMBL2076808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1743122) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cloning and characterization of two human polyspecific organic cation transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197556 | — | — | 1 | 7.00 |
| CHEMBL2074851 | Cyanine-863 | — | 1 | 6.68 |
| CHEMBL2074704 | TETRAPENTYLAMMONIUM | — | 1 | 5.82 |
| CHEMBL311617 | — | — | 1 | 5.62 |
| CHEMBL170 | QUININE | 4.0 | 1 | 5.47 |
| CHEMBL2074659 | MEPIPERPHENIDOL BROMIDE | -1.0 | 1 | 5.32 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 4.80 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 4.30 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | — | 1 | - |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | -1.0 | 1 | - |
| CHEMBL2074647 | METIPRENALINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197556 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2074851 | Cyanine-863 | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2074704 | TETRAPENTYLAMMONIUM | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL311617 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL170 | QUININE | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2074659 | MEPIPERPHENIDOL BROMIDE | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL72 | DESIPRAMINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL640 | PROCAINAMIDE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | Ki | = | 180000.0 | nM | - |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | Ki | = | 266000.0 | nM | - |
| CHEMBL2074647 | METIPRENALINE | Ki | = | 570000.0 | nM | - |