Assay Detail
Functional
CHEMBL2077061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HRPE |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 3 (CHEMBL1770033) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.33 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 5.96 |
| CHEMBL110739 | CORTICOSTERONE | 3.0 | 1 | 5.31 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | — | 1 | 5.08 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.98 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | - |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL110739 | CORTICOSTERONE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL59 | DOPAMINE | IC50 | = | 384000.0 | nM | - |
| CHEMBL1437 | NOREPINEPHRINE | IC50 | = | 434000.0 | nM | - |