Assay Detail
Functional
CHEMBL2077576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 2A1 (CHEMBL2073680) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structural determinants of substrates for the prostaglandin transporter PGT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.98 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074582 | PROSTAGLANDIN H2 | — | 1 | 7.42 |
| CHEMBL1561148 | PROSTAGLANDIN B1 | — | 1 | 7.15 |
| CHEMBL2075005 | PROSTAGLANDIN D1 | — | 1 | 6.79 |
| CHEMBL1084644 | PROSTAGLANDIN A1 | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074582 | PROSTAGLANDIN H2 | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL1561148 | PROSTAGLANDIN B1 | Ki | = | 71.2 | nM | 7.15 |
| CHEMBL2075005 | PROSTAGLANDIN D1 | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL1084644 | PROSTAGLANDIN A1 | Ki | = | 286.0 | nM | 6.54 |