Assay Detail
Functional
CHEMBL2090339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in human THP1 cells pre-incubated for before LPS challenge and measured 4 hrs post LPS challenge by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.42 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088588 | — | — | 1 | 8.36 |
| CHEMBL2088591 | — | — | 1 | 8.34 |
| CHEMBL2088578 | — | — | 1 | 8.28 |
| CHEMBL1098524 | — | — | 1 | 8.25 |
| CHEMBL2088582 | — | — | 1 | 8.06 |
| CHEMBL2088575 | — | — | 1 | 7.75 |
| CHEMBL2088583 | — | — | 1 | 7.72 |
| CHEMBL1096192 | — | — | 1 | 7.60 |
| CHEMBL2088586 | — | — | 1 | 7.54 |
| CHEMBL2088576 | — | — | 1 | 7.39 |
| CHEMBL2088580 | — | — | 1 | 7.37 |
| CHEMBL2088585 | — | — | 1 | 7.35 |
| CHEMBL2088590 | — | — | 1 | 7.34 |
| CHEMBL2088577 | — | — | 1 | 7.33 |
| CHEMBL2088579 | — | — | 1 | 7.10 |
| CHEMBL2088589 | — | — | 1 | 7.06 |
| CHEMBL2088587 | — | — | 1 | 6.92 |
| CHEMBL2088584 | — | — | 1 | 6.92 |
| CHEMBL1098546 | — | — | 1 | 6.02 |
| CHEMBL2088581 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088588 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2088591 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2088578 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1098524 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2088582 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2088575 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2088583 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1096192 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2088586 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2088576 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2088580 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2088585 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2088590 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2088577 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2088579 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2088589 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2088587 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2088584 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1098546 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL2088581 | — | IC50 | = | 2000.0 | nM | 5.70 |