Assay Detail
Binding
CHEMBL2090703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by ELISA
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.98 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087874 | — | — | 1 | 9.70 |
| CHEMBL2087875 | — | — | 1 | 9.52 |
| CHEMBL2087873 | — | — | 1 | 9.52 |
| CHEMBL2087652 | — | — | 1 | 8.70 |
| CHEMBL2087654 | — | — | 1 | 8.70 |
| CHEMBL2087662 | — | — | 1 | 8.70 |
| CHEMBL2087664 | — | — | 1 | 8.52 |
| CHEMBL2087879 | — | — | 1 | 8.40 |
| CHEMBL2087659 | — | — | 1 | 8.40 |
| CHEMBL2087660 | — | — | 1 | 8.40 |
| CHEMBL2087656 | — | — | 1 | 8.40 |
| CHEMBL2087653 | — | — | 1 | 8.40 |
| CHEMBL2087872 | — | — | 1 | 8.40 |
| CHEMBL2087648 | — | — | 1 | 8.30 |
| CHEMBL247479 | — | — | 1 | 8.30 |
| CHEMBL2087658 | — | — | 1 | 8.22 |
| CHEMBL2087647 | — | — | 1 | 8.22 |
| CHEMBL2087649 | — | — | 1 | 8.22 |
| CHEMBL2087666 | — | — | 1 | 8.22 |
| CHEMBL2087665 | — | — | 1 | 8.22 |
| CHEMBL2087655 | — | — | 1 | 8.22 |
| CHEMBL2087657 | — | — | 1 | 8.22 |
| CHEMBL2087651 | — | — | 1 | 8.15 |
| CHEMBL2087876 | — | — | 1 | 8.10 |
| CHEMBL2087650 | — | — | 1 | 8.10 |
| CHEMBL2087661 | — | — | 1 | 8.00 |
| CHEMBL2087671 | — | — | 1 | 8.00 |
| CHEMBL2087667 | — | — | 1 | 8.00 |
| CHEMBL2087877 | — | — | 1 | 7.89 |
| CHEMBL2087663 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087874 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2087875 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2087873 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2087652 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2087654 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2087662 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2087664 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2087659 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087660 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087656 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087879 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087653 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087872 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2087648 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL247479 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2087658 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087657 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087655 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087665 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087666 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087649 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087647 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2087651 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL2087650 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2087876 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2087661 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2087671 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2087667 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2087877 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2087663 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2087881 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2087668 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2087871 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2087880 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2087670 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL2087882 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL2087883 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2087884 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2087878 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL240429 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2087887 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL2087669 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL2087886 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL2087885 | — | Ki | > | 10000.0 | nM | - |