Assay Detail
Binding
CHEMBL2090846
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Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.44 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.47 |
| CHEMBL2089156 | — | — | 1 | 8.24 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 7.98 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 7.55 |
| CHEMBL1276140 | — | — | 1 | 7.45 |
| CHEMBL2089155 | — | — | 1 | 7.40 |
| CHEMBL17860 | LOFEXIDINE | 4.0 | 1 | 6.90 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 5.49 |
| CHEMBL1276139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 3.388 | nM | 8.47 |
| CHEMBL2089156 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL1956195 | CYCLOMETHYLINE | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL495095 | ALLYPHENYLINE | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL1276140 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL2089155 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL17860 | LOFEXIDINE | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL134 | CLONIDINE | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL1276139 | — | Ki | > | 10000.0 | nM | - |