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Assay Detail

CHEMBL2149153

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ram seminal vesicle COX1 assessed as PGE2 production by enzyme immunoassay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Tissue Seminal vesicle
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL2949)
Type SINGLE PROTEIN
Organism Ovis aries

Publication

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Favero GD, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Loggia RD, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H.
J Nat Prod (2011) 74 : 1779 -1786
PubMed 21800856 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.39 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6 INDOMETHACIN 4.0 1 5.68
CHEMBL2147423 RATANIAPHENOL III 1 5.57
CHEMBL463574 RATANIAPHENOL II 1 5.52
CHEMBL2147420 1 5.42
CHEMBL2147422 1 4.74
CHEMBL2147421 1 -
CHEMBL2147424 RATANIAPHENOL I 1 -
CHEMBL2147415 1 -
CHEMBL2147416 1 -
CHEMBL2147417 1 -
CHEMBL2147418 1 -
CHEMBL2147419 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6 INDOMETHACIN IC50 = 2100.0 nM 5.68
CHEMBL2147423 RATANIAPHENOL III IC50 = 2700.0 nM 5.57
CHEMBL463574 RATANIAPHENOL II IC50 = 3000.0 nM 5.52
CHEMBL2147420 IC50 = 3800.0 nM 5.42
CHEMBL2147422 IC50 = 18300.0 nM 4.74
CHEMBL2147421 IC50 > 50000.0 nM -
CHEMBL2147424 RATANIAPHENOL I IC50 > 50000.0 nM -
CHEMBL2147415 IC50 > 50000.0 nM -
CHEMBL2147416 IC50 > 50000.0 nM -
CHEMBL2147417 IC50 > 50000.0 nM -
CHEMBL2147418 IC50 > 50000.0 nM -
CHEMBL2147419 IC50 > 50000.0 nM -