Assay Detail
ADMET
CHEMBL2154123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MATE1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug and toxin extrusion protein 1 (CHEMBL1743126) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.14 | 6.82 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL95 | TACRINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL30 | CIMETIDINE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL900 | ORPHENADRINE | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL517 | DISOPYRAMIDE | IC50 | = | 66000.0 | nM | 4.18 |