Assay Detail
Functional
CHEMBL2154361
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Antiviral activity against Influenza B/HK/5/72 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect measured on day 3 post infection by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.11 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151341 | — | — | 1 | 5.85 |
| CHEMBL2151342 | — | — | 1 | 5.05 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.05 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 4.47 |
| CHEMBL2151338 | — | — | 1 | - |
| CHEMBL2151339 | — | — | 1 | - |
| CHEMBL2151340 | — | — | 1 | - |
| CHEMBL2151343 | — | — | 1 | - |
| CHEMBL2151344 | — | — | 1 | - |
| CHEMBL2151345 | — | — | 1 | - |
| CHEMBL2151346 | AGLYCORISTOCETIN | — | 1 | - |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151341 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2151342 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2151338 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151339 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151340 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151343 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151344 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151345 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2151346 | AGLYCORISTOCETIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL660 | AMANTADINE | EC50 | > | 500000.0 | nM | - |