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Compound Detail

CHEMBL2151341

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COC(=O)[C@H]1NC(=O)[C@H]2NC(=O)[C@H](NC(=O)[C@@H]3NC(=O)[C@H]4NC(=O)[C@H](NC(=O)[C@H](n5cc6ccccc6c5Sc5ccccc5)c5ccc(O)c(c5)Oc5cc4cc(O)c5C)[C@H](O)c4ccc(cc4)Oc4cc3cc(c4O)Oc3ccc(cc3)[C@H]2O)c2ccc(O)c(c2)-c2c(O)cc(O)cc21

Basic Information

ChEMBL ID CHEMBL2151341
Phase Preclinical
Structure Type MOL
InChI Key OWHVZDHFLUCVCG-PXPTYPKCSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

1382.4
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C74H59N7O19S
MW 1382.38

Activity Summary

EC50 3 meas. best 6.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
H3N2 subtype
CHEMBL613193
EC50 6.17 6.17 680.0 1
Influenza A virus
CHEMBL613740
EC50 6.17 6.17 670.0 1
Influenza B virus
CHEMBL613129
EC50 5.85 5.85 1400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23149298 10.1016/j.ejmech.2012.10.030 Enterococcus faecalis 3
23149298 10.1016/j.ejmech.2012.10.030 Staphylococcus aureus 2
23149298 10.1016/j.ejmech.2012.10.030 Staphylococcus epidermidis 2
23149298 10.1016/j.ejmech.2012.10.030 Bacillus subtilis 1
23149298 10.1016/j.ejmech.2012.10.030 Influenza A virus 1
23149298 10.1016/j.ejmech.2012.10.030 H3N2 subtype 1
23149298 10.1016/j.ejmech.2012.10.030 Influenza B virus 1
23149298 10.1016/j.ejmech.2012.10.030 MDCK 1

Data from ChEMBL 36 via Core Engine