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Assay Detail

CHEMBL2154447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membranes after 1 hr by scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 2 (CHEMBL253)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.
Gembus V, Furman C, Millet R, Mansouri R, Chavatte P, Levacher V, Brière JF.
Eur J Med Chem (2012) 58 : 396 -404
PubMed 23151320 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.73 8.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL188 WIN-552122 1 8.51
CHEMBL381689 SR-144528 1 7.67
CHEMBL2151380 1 6.60
CHEMBL2151379 1 6.42
CHEMBL2151370 1 6.30
CHEMBL2151377 1 6.16
CHEMBL2151381 1 5.44
CHEMBL2151368 1 -
CHEMBL2151369 1 -
CHEMBL2151371 1 -
CHEMBL2151372 1 -
CHEMBL2151373 1 -
CHEMBL2151374 1 -
CHEMBL2151375 1 -
CHEMBL2151376 1 -
CHEMBL2151378 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL188 WIN-552122 Ki = 3.1 nM 8.51
CHEMBL381689 SR-144528 Ki = 21.6 nM 7.67
CHEMBL2151380 Ki = 251.0 nM 6.60
CHEMBL2151379 Ki = 385.0 nM 6.42
CHEMBL2151370 Ki = 504.0 nM 6.30
CHEMBL2151377 Ki = 689.0 nM 6.16
CHEMBL2151381 Ki = 3639.0 nM 5.44
CHEMBL2151368 Ki > 3000.0 nM -
CHEMBL2151369 Ki > 3000.0 nM -
CHEMBL2151371 Ki > 3000.0 nM -
CHEMBL2151372 Ki > 3000.0 nM -
CHEMBL2151373 Ki > 3000.0 nM -
CHEMBL2151374 Ki > 3000.0 nM -
CHEMBL2151375 Ki > 3000.0 nM -
CHEMBL2151376 Ki > 1000.0 nM -
CHEMBL2151378 Ki > 1000.0 nM -