Compound Detail
CHEMBL2151380
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Cc1ccc(CC2CN(C(=O)NC3C4(C)CCC(C4)C3(C)C)N=C2c2ccc(Cl)c(C)c2)cc1
Basic Information
| ChEMBL ID | CHEMBL2151380 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAZCFFCYWUHWFV-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
478.1
MW (Da)
6.76
ALogP
2
HBA
1
HBD
44.7
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.72
Ki 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 2 CHEMBL253 | EC50 | 6.72 | 6.72 | 191.0 | 1 |
| Cannabinoid receptor 2 CHEMBL253 | Ki | 6.6 | 6.6 | 251.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 2 | EC50 | = | 191.0 | nM | 6.72 | Agonist activity at human CB2 receptor expressed in CHO cell membranes after 1 h... | 23151320 |
| Cannabinoid receptor 2 | Ki | = | 251.0 | nM | 6.6 | Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membra... | 23151320 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23151320 | 10.1016/j.ejmech.2012.10.031 | Cannabinoid receptor 2 | 3 |
| 23151320 | 10.1016/j.ejmech.2012.10.031 | Cannabinoid receptor 1 | 1 |
| 23151320 | 10.1016/j.ejmech.2012.10.031 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine