Assay Detail
Functional
CHEMBL2154449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CB2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.92 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | — | 1 | 8.68 |
| CHEMBL188 | WIN-552122 | — | 1 | 7.05 |
| CHEMBL2151380 | — | — | 1 | 6.72 |
| CHEMBL2151370 | — | — | 1 | 6.53 |
| CHEMBL2151379 | — | — | 1 | 6.43 |
| CHEMBL2151377 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL188 | WIN-552122 | EC50 | = | 89.6 | nM | 7.05 |
| CHEMBL2151380 | — | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL2151370 | — | EC50 | = | 297.0 | nM | 6.53 |
| CHEMBL2151379 | — | EC50 | = | 371.0 | nM | 6.43 |
| CHEMBL2151377 | — | EC50 | = | 749.0 | nM | 6.13 |