Assay Detail
Binding
CHEMBL2155177
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Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | ScN2a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.79 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153292 | — | — | 1 | 7.57 |
| CHEMBL2153289 | — | — | 1 | 7.46 |
| CHEMBL2153413 | — | — | 1 | 7.27 |
| CHEMBL2153290 | — | — | 1 | 7.22 |
| CHEMBL2153301 | — | — | 1 | 7.12 |
| CHEMBL2153288 | — | — | 1 | 7.10 |
| CHEMBL2153295 | — | — | 1 | 7.09 |
| CHEMBL2153298 | — | — | 1 | 7.09 |
| CHEMBL2151063 | — | — | 1 | 7.03 |
| CHEMBL2153414 | — | — | 1 | 7.00 |
| CHEMBL512898 | — | — | 1 | 7.00 |
| CHEMBL2153300 | — | — | 1 | 6.89 |
| CHEMBL1424003 | — | — | 1 | 6.85 |
| CHEMBL2153296 | — | — | 1 | 6.82 |
| CHEMBL2153416 | — | — | 1 | 6.82 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.64 |
| CHEMBL2153297 | — | — | 1 | 6.55 |
| CHEMBL472113 | — | — | 1 | 6.38 |
| CHEMBL2153293 | — | — | 1 | 6.27 |
| CHEMBL2153415 | — | — | 1 | 6.27 |
| CHEMBL2153299 | — | — | 1 | 6.26 |
| CHEMBL2153291 | — | — | 1 | 5.91 |
| CHEMBL2153294 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153292 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2153289 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2153413 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2153290 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2153301 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2153288 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2153295 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2153298 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2151063 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2153414 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL512898 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2153300 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1424003 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2153296 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2153416 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL7568 | QUINACRINE | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2153297 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL472113 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2153293 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2153415 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2153299 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2153291 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2153294 | — | EC50 | = | 2510.0 | nM | 5.60 |