Assay Detail
Binding
CHEMBL2155179
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Antiprion activity against mouse prion protein 22L infected mouse N167 cells assessed as reduction of PrPSc level by Western blot method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | N167 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.33 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153299 | — | — | 1 | 6.85 |
| CHEMBL2153416 | — | — | 1 | 6.64 |
| CHEMBL2153300 | — | — | 1 | 6.64 |
| CHEMBL2153301 | — | — | 1 | 6.52 |
| CHEMBL2151063 | — | — | 1 | 6.50 |
| CHEMBL2153297 | — | — | 1 | 6.47 |
| CHEMBL2153290 | — | — | 1 | 6.46 |
| CHEMBL2153413 | — | — | 1 | 6.46 |
| CHEMBL2153415 | — | — | 1 | 6.38 |
| CHEMBL512898 | — | — | 1 | 6.38 |
| CHEMBL472113 | — | — | 1 | 6.31 |
| CHEMBL2153414 | — | — | 1 | 6.29 |
| CHEMBL1424003 | — | — | 1 | 6.28 |
| CHEMBL2153298 | — | — | 1 | 6.28 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.23 |
| CHEMBL2153296 | — | — | 1 | 6.21 |
| CHEMBL2153288 | — | — | 1 | 6.02 |
| CHEMBL2153292 | — | — | 1 | 6.00 |
| CHEMBL2153291 | — | — | 1 | 5.38 |
| CHEMBL2153295 | — | — | 1 | - |
| CHEMBL2153294 | — | — | 1 | - |
| CHEMBL2153293 | — | — | 1 | - |
| CHEMBL2153289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153299 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2153416 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2153300 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2153301 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2151063 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2153297 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2153290 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2153413 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2153415 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL512898 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL472113 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2153414 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1424003 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2153298 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL7568 | QUINACRINE | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2153296 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2153288 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL2153292 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2153291 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2153295 | — | EC50 | - | — | - | |
| CHEMBL2153294 | — | EC50 | - | — | - | |
| CHEMBL2153293 | — | EC50 | - | — | - | |
| CHEMBL2153289 | — | EC50 | - | — | - |