Assay Detail
Binding
CHEMBL2155181
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Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | N2a #58 F3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.04 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153300 | — | — | 1 | 6.72 |
| CHEMBL2153413 | — | — | 1 | 6.27 |
| CHEMBL2153296 | — | — | 1 | 6.20 |
| CHEMBL2153414 | — | — | 1 | 6.19 |
| CHEMBL512898 | — | — | 1 | 6.17 |
| CHEMBL2153301 | — | — | 1 | 6.16 |
| CHEMBL472113 | — | — | 1 | 6.10 |
| CHEMBL2153290 | — | — | 1 | 6.07 |
| CHEMBL2151063 | — | — | 1 | 5.98 |
| CHEMBL2153416 | — | — | 1 | 5.92 |
| CHEMBL2153415 | — | — | 1 | 5.92 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.73 |
| CHEMBL1424003 | — | — | 1 | 5.69 |
| CHEMBL2153291 | — | — | 1 | 5.39 |
| CHEMBL2153297 | — | — | 1 | - |
| CHEMBL2153298 | — | — | 1 | - |
| CHEMBL2153299 | — | — | 1 | - |
| CHEMBL2153295 | — | — | 1 | - |
| CHEMBL2153294 | — | — | 1 | - |
| CHEMBL2153293 | — | — | 1 | - |
| CHEMBL2153292 | — | — | 1 | - |
| CHEMBL2153289 | — | — | 1 | - |
| CHEMBL2153288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153300 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2153413 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2153296 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2153414 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL512898 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2153301 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL472113 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2153290 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2151063 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL2153416 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2153415 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL7568 | QUINACRINE | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL1424003 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL2153291 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2153297 | — | EC50 | - | — | - | |
| CHEMBL2153298 | — | EC50 | - | — | - | |
| CHEMBL2153299 | — | EC50 | - | — | - | |
| CHEMBL2153295 | — | EC50 | - | — | - | |
| CHEMBL2153294 | — | EC50 | - | — | - | |
| CHEMBL2153293 | — | EC50 | - | — | - | |
| CHEMBL2153292 | — | EC50 | - | — | - | |
| CHEMBL2153289 | — | EC50 | - | — | - | |
| CHEMBL2153288 | — | EC50 | - | — | - |