Assay Detail
Binding
CHEMBL2155294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2-mediated 2-arachidonoylglycerol oxygenation in LPS/IFN-gamma-stimulated mouse RAW264.7 cells assessed as 2-AG to PGE2-G/PGD2-G conversion treated 2 hrs after LPS/IFN-gamma stimulation measured after 6 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.60 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152245 | DESMETHYLFLURBIPROFEN | — | 1 | 6.22 |
| CHEMBL190083 | TARENFLURBIL | 3.0 | 1 | 5.89 |
| CHEMBL380853 | — | — | 1 | 5.28 |
| CHEMBL194760 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152245 | DESMETHYLFLURBIPROFEN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL190083 | TARENFLURBIL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL380853 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL194760 | — | IC50 | = | 10200.0 | nM | 4.99 |