Assay Detail
Functional
CHEMBL2156018
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Cytotoxicity against human T47D cells after 48 hrs by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.27 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336253 | ADOCIAQUINONE A | — | 1 | 5.58 |
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 5.54 |
| CHEMBL2153503 | — | — | 1 | 5.44 |
| CHEMBL2153504 | — | — | 1 | 5.37 |
| CHEMBL510492 | XESTOQUINONE | — | 1 | 4.86 |
| CHEMBL2153505 | — | — | 1 | 4.80 |
| CHEMBL1208027 | XESTOQUINOL SULFATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336253 | ADOCIAQUINONE A | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2153503 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2153504 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL510492 | XESTOQUINONE | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL2153505 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL1208027 | XESTOQUINOL SULFATE | IC50 | > | 30000.0 | nM | - |