Assay Detail
Functional
CHEMBL2156472
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Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Camptothecins in tumor homing via an RGD sequence mimetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.74 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112769 | — | — | 1 | 9.40 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 8.40 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 8.22 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.05 |
| CHEMBL2153643 | — | — | 1 | 7.48 |
| CHEMBL2153645 | — | — | 1 | 7.17 |
| CHEMBL2153644 | — | — | 1 | 6.96 |
| CHEMBL2153646 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112769 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2153643 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2153645 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2153644 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2153646 | — | IC50 | = | 570.0 | nM | 6.24 |