Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2157357

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiangiogenic activity in SV-40T transfected human HMEC1 cells assessed as inhibition of cell proliferation after 72 hrs by crystal violet staining
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HMEC-1
Confidence 1 — Organism
Curated By Autocuration

Publication

Bi-, tri-, and polycyclic acylphloroglucinols from Hypericum empetrifolium.
Schmidt S, Jürgenliemk G, Schmidt TJ, Skaltsa H, Heilmann J.
J Nat Prod (2012) 75 : 1697 -1705
PubMed 23030826 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.74 5.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2152500 EMPETRIFRANZINAN C 1 5.04
CHEMBL253896 XANTHOHUMOL 2.0 1 4.94
CHEMBL2152496 1 4.88
CHEMBL2152492 EMPETRIKARINEN B 1 4.82
CHEMBL469854 1 4.78
CHEMBL2152498 EMPETRIFERDINAN B 1 4.78
CHEMBL2152494 EMPETRIKARINOL B 1 4.74
CHEMBL2152495 1 4.68
CHEMBL2152493 EMPETRIKARINOL A 1 4.63
CHEMBL2152491 EMPETRIKARINEN A 1 4.61
CHEMBL2152497 EMPETRIFERDINAN A 1 4.61
CHEMBL2152499 EMPETRIFERDINOL 1 4.54
CHEMBL470257 1 4.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2152500 EMPETRIFRANZINAN C IC50 = 9200.0 nM 5.04
CHEMBL253896 XANTHOHUMOL IC50 = 11400.0 nM 4.94
CHEMBL2152496 IC50 = 13300.0 nM 4.88
CHEMBL2152492 EMPETRIKARINEN B IC50 = 15000.0 nM 4.82
CHEMBL469854 IC50 = 16500.0 nM 4.78
CHEMBL2152498 EMPETRIFERDINAN B IC50 = 16600.0 nM 4.78
CHEMBL2152494 EMPETRIKARINOL B IC50 = 18400.0 nM 4.74
CHEMBL2152495 IC50 = 21100.0 nM 4.68
CHEMBL2152493 EMPETRIKARINOL A IC50 = 23400.0 nM 4.63
CHEMBL2152491 EMPETRIKARINEN A IC50 = 24400.0 nM 4.61
CHEMBL2152497 EMPETRIFERDINAN A IC50 = 24400.0 nM 4.61
CHEMBL2152499 EMPETRIFERDINOL IC50 = 29200.0 nM 4.54
CHEMBL470257 IC50 = 29600.0 nM 4.53