Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2163095

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to rat delta opioid receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL269)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Breslin HJ, Diamond CJ, Kavash RW, Cai C, Dyatkin AB, Miskowski TA, Zhang SP, Wade PR, Hornby PJ, He W.
Bioorg Med Chem Lett (2012) 22 : 4869 -4872
PubMed 22695132 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.01 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL427214 1 10.22
CHEMBL208454 1 10.00
CHEMBL2159120 1 9.30
CHEMBL361274 1 9.05
CHEMBL2159122 ELUXADOLINE 4.0 1 8.89
CHEMBL2159117 1 8.85
CHEMBL2159118 1 8.82
CHEMBL377069 1 8.72
CHEMBL2159119 1 7.92
CHEMBL205049 1 7.85
CHEMBL2159115 1 7.82
CHEMBL2159116 1 7.82
CHEMBL2159114 1 7.58
CHEMBL2159113 1 6.59
CHEMBL2159111 1 6.15
CHEMBL2159112 1 5.28
CHEMBL2159015 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL427214 Ki = 0.06 nM 10.22
CHEMBL208454 Ki = 0.1 nM 10.00
CHEMBL2159120 Ki = 0.5 nM 9.30
CHEMBL361274 Ki = 0.9 nM 9.05
CHEMBL2159122 ELUXADOLINE Ki = 1.3 nM 8.89
CHEMBL2159117 Ki = 1.4 nM 8.85
CHEMBL2159118 Ki = 1.5 nM 8.82
CHEMBL377069 Ki = 1.9 nM 8.72
CHEMBL2159119 Ki = 12.0 nM 7.92
CHEMBL205049 Ki = 14.0 nM 7.85
CHEMBL2159115 Ki = 15.0 nM 7.82
CHEMBL2159116 Ki = 15.0 nM 7.82
CHEMBL2159114 Ki = 26.0 nM 7.58
CHEMBL2159113 Ki = 255.0 nM 6.59
CHEMBL2159111 Ki = 708.0 nM 6.15
CHEMBL2159112 Ki = 5198.0 nM 5.28
CHEMBL2159015 Ki = 5660.0 nM 5.25