Assay Detail
Binding
CHEMBL2166019
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Inhibition of human BChE by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.47 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1512936 | SEVEDINDIONE | — | 1 | 6.57 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.91 |
| CHEMBL2163794 | OXYACANTHINE SULFATE | — | 1 | 5.72 |
| CHEMBL327134 | HIRSUTINE | — | 1 | 5.71 |
| CHEMBL405686 | E6 BERBAMINE | — | 1 | 5.67 |
| CHEMBL2163793 | CATHARANTHINE BASE | — | 1 | 5.50 |
| CHEMBL2163791 | VASICINE | — | 1 | 5.50 |
| CHEMBL3216788 | — | — | 1 | 5.04 |
| CHEMBL258893 | CHELERYTHRINE CHLORIDE | — | 1 | 4.99 |
| CHEMBL1257131 | RAUWOLSCINE HYDROCHLORIDE | — | 1 | 4.86 |
| CHEMBL464724 | VERATRAMINE | — | 1 | 4.71 |
| CHEMBL2165578 | PEGANOLE | — | 1 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
| CHEMBL2163795 | PALMATINE CHLORIDE HYDRATE | — | 1 | - |
| CHEMBL2163792 | DESOXYPEGANINE HYDROCHLORIDE HYDRATE | — | 1 | - |
| CHEMBL277642 | HIMBACINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1512936 | SEVEDINDIONE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2163794 | OXYACANTHINE SULFATE | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL327134 | HIRSUTINE | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL405686 | E6 BERBAMINE | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL2163793 | CATHARANTHINE BASE | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL2163791 | VASICINE | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL3216788 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL258893 | CHELERYTHRINE CHLORIDE | IC50 | = | 10340.0 | nM | 4.99 |
| CHEMBL1257131 | RAUWOLSCINE HYDROCHLORIDE | IC50 | = | 13680.0 | nM | 4.86 |
| CHEMBL464724 | VERATRAMINE | IC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL2165578 | PEGANOLE | IC50 | > | 20000.0 | nM | - |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | - | — | - | |
| CHEMBL2163795 | PALMATINE CHLORIDE HYDRATE | IC50 | - | — | - | |
| CHEMBL2163792 | DESOXYPEGANINE HYDROCHLORIDE HYDRATE | IC50 | - | — | - | |
| CHEMBL277642 | HIMBACINE | IC50 | - | — | - |