Assay Detail
Functional
CHEMBL2166468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei bloodstream form overexpressing nitroreductase assessed as growth inhibition after 3 days by Alamar blue assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.49 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.58 |
| CHEMBL2165514 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2165514 | — | IC50 | = | 39900.0 | nM | 4.40 |