Assay Detail
Functional
CHEMBL2166469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against wild type Trypanosoma brucei bloodstream form assessed as growth inhibition after 3 days by Alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.07 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.74 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 5.08 |
| CHEMBL2165514 | — | — | 1 | 4.40 |
| CHEMBL2165518 | — | — | 1 | - |
| CHEMBL2165517 | — | — | 1 | - |
| CHEMBL2165516 | — | — | 1 | - |
| CHEMBL2165515 | — | — | 1 | - |
| CHEMBL2165397 | — | — | 1 | - |
| CHEMBL2165396 | — | — | 1 | - |
| CHEMBL2165395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL830 | EFLORNITHINE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2165514 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL2165518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165516 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165515 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165397 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2165395 | — | IC50 | > | 100000.0 | nM | - |