Assay Detail
Functional
CHEMBL2167060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.53 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 8.80 |
| CHEMBL2164800 | — | — | 1 | 7.96 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.60 |
| CHEMBL2164804 | — | — | 1 | 7.48 |
| CHEMBL2164798 | — | — | 1 | 7.35 |
| CHEMBL2164791 | — | — | 1 | 7.25 |
| CHEMBL2164799 | — | — | 1 | 7.23 |
| CHEMBL2164802 | — | — | 1 | 7.18 |
| CHEMBL2164805 | — | — | 1 | 6.70 |
| CHEMBL2164806 | — | — | 1 | 6.22 |
| CHEMBL2164796 | — | — | 1 | 6.16 |
| CHEMBL2164795 | — | — | 1 | 6.15 |
| CHEMBL2164808 | — | — | 1 | 6.11 |
| CHEMBL2164793 | — | — | 1 | 6.07 |
| CHEMBL2164801 | — | — | 1 | 5.77 |
| CHEMBL2164807 | — | — | 1 | 5.77 |
| CHEMBL2164797 | — | — | 1 | 5.75 |
| CHEMBL2164803 | — | — | 1 | 5.65 |
| CHEMBL2164792 | — | — | 1 | 5.50 |
| CHEMBL2164809 | — | — | 1 | 5.45 |
| CHEMBL2164794 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL2164800 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164804 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2164798 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2164791 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2164799 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2164802 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2164805 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2164806 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2164796 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2164795 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2164808 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2164793 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2164801 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2164807 | — | IC50 | = | 1709.0 | nM | 5.77 |
| CHEMBL2164797 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2164803 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL2164792 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2164809 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL2164794 | — | IC50 | = | 10300.0 | nM | 4.99 |