Assay Detail
Binding
CHEMBL2167536
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Displacement of [125I]-BNtxA from mouse cloned MOR-1 expressed in CHO cell membrane after 90 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.94 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163536 | — | — | 1 | 9.96 |
| CHEMBL1795711 | — | — | 1 | 9.96 |
| CHEMBL2163543 | — | — | 1 | 9.74 |
| CHEMBL1795712 | — | — | 1 | 9.66 |
| CHEMBL2163546 | — | — | 1 | 9.64 |
| CHEMBL2163541 | — | — | 1 | 9.54 |
| CHEMBL2163544 | — | — | 1 | 9.37 |
| CHEMBL2163537 | — | — | 1 | 9.33 |
| CHEMBL2164301 | — | — | 1 | 9.21 |
| CHEMBL2164296 | — | — | 1 | 9.18 |
| CHEMBL2164297 | — | — | 1 | 9.13 |
| CHEMBL2163542 | — | — | 1 | 9.07 |
| CHEMBL2164298 | — | — | 1 | 9.02 |
| CHEMBL1795713 | — | — | 1 | 9.01 |
| CHEMBL2163538 | — | — | 1 | 8.94 |
| CHEMBL2164295 | — | — | 1 | 8.85 |
| CHEMBL2163535 | — | — | 1 | 8.81 |
| CHEMBL2163539 | — | — | 1 | 8.41 |
| CHEMBL2163540 | — | — | 1 | 8.39 |
| CHEMBL2163534 | — | — | 1 | 8.29 |
| CHEMBL2163532 | — | — | 1 | 8.19 |
| CHEMBL2163545 | — | — | 1 | 8.19 |
| CHEMBL2164300 | — | — | 1 | 8.02 |
| CHEMBL2163531 | — | — | 1 | 7.94 |
| CHEMBL2164299 | — | — | 1 | 7.69 |
| CHEMBL2163533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163536 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL1795711 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL2163543 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL1795712 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL2163546 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2163541 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2163544 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL2163537 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL2164301 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL2164296 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL2164297 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL2163542 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL2164298 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL1795713 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL2163538 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL2164295 | — | Ki | = | 1.41 | nM | 8.85 |
| CHEMBL2163535 | — | Ki | = | 1.56 | nM | 8.81 |
| CHEMBL2163539 | — | Ki | = | 3.85 | nM | 8.41 |
| CHEMBL2163540 | — | Ki | = | 4.03 | nM | 8.39 |
| CHEMBL2163534 | — | Ki | = | 5.07 | nM | 8.29 |
| CHEMBL2163532 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL2163545 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL2164300 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL2163531 | — | Ki | = | 11.54 | nM | 7.94 |
| CHEMBL2164299 | — | Ki | = | 20.46 | nM | 7.69 |
| CHEMBL2163533 | — | Ki | > | 100.0 | nM | - |