Assay Detail
Binding
CHEMBL2167538
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Displacement of [125I]-BNtxA from mouse cloned DOR-1 expressed in CHO cell membrane after 90 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.99 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795711 | — | — | 1 | 9.62 |
| CHEMBL1795713 | — | — | 1 | 8.61 |
| CHEMBL1795712 | — | — | 1 | 8.59 |
| CHEMBL2163542 | — | — | 1 | 8.53 |
| CHEMBL2163536 | — | — | 1 | 8.47 |
| CHEMBL2163538 | — | — | 1 | 8.31 |
| CHEMBL2164297 | — | — | 1 | 8.26 |
| CHEMBL2163534 | — | — | 1 | 8.12 |
| CHEMBL2163541 | — | — | 1 | 8.08 |
| CHEMBL2163546 | — | — | 1 | 7.95 |
| CHEMBL2164301 | — | — | 1 | 7.82 |
| CHEMBL2163543 | — | — | 1 | 7.76 |
| CHEMBL2164296 | — | — | 1 | 7.75 |
| CHEMBL2164295 | — | — | 1 | 7.74 |
| CHEMBL2163537 | — | — | 1 | 7.74 |
| CHEMBL2164298 | — | — | 1 | 7.72 |
| CHEMBL2163535 | — | — | 1 | 7.64 |
| CHEMBL2163539 | — | — | 1 | 7.63 |
| CHEMBL2164300 | — | — | 1 | 7.49 |
| CHEMBL2163544 | — | — | 1 | 7.44 |
| CHEMBL2163545 | — | — | 1 | 7.29 |
| CHEMBL2163540 | — | — | 1 | 7.22 |
| CHEMBL2163533 | — | — | 1 | - |
| CHEMBL2164299 | — | — | 1 | - |
| CHEMBL2163531 | — | — | 1 | - |
| CHEMBL2163532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795711 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1795713 | — | Ki | = | 2.45 | nM | 8.61 |
| CHEMBL1795712 | — | Ki | = | 2.55 | nM | 8.59 |
| CHEMBL2163542 | — | Ki | = | 2.96 | nM | 8.53 |
| CHEMBL2163536 | — | Ki | = | 3.36 | nM | 8.47 |
| CHEMBL2163538 | — | Ki | = | 4.87 | nM | 8.31 |
| CHEMBL2164297 | — | Ki | = | 5.51 | nM | 8.26 |
| CHEMBL2163534 | — | Ki | = | 7.64 | nM | 8.12 |
| CHEMBL2163541 | — | Ki | = | 8.24 | nM | 8.08 |
| CHEMBL2163546 | — | Ki | = | 11.25 | nM | 7.95 |
| CHEMBL2164301 | — | Ki | = | 15.25 | nM | 7.82 |
| CHEMBL2163543 | — | Ki | = | 17.22 | nM | 7.76 |
| CHEMBL2164296 | — | Ki | = | 17.88 | nM | 7.75 |
| CHEMBL2164295 | — | Ki | = | 18.13 | nM | 7.74 |
| CHEMBL2163537 | — | Ki | = | 18.19 | nM | 7.74 |
| CHEMBL2164298 | — | Ki | = | 19.15 | nM | 7.72 |
| CHEMBL2163535 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL2163539 | — | Ki | = | 23.37 | nM | 7.63 |
| CHEMBL2164300 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL2163544 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2163545 | — | Ki | = | 51.35 | nM | 7.29 |
| CHEMBL2163540 | — | Ki | = | 60.78 | nM | 7.22 |
| CHEMBL2163533 | — | Ki | > | 100.0 | nM | - |
| CHEMBL2164299 | — | Ki | > | 100.0 | nM | - |
| CHEMBL2163531 | — | Ki | > | 100.0 | nM | - |
| CHEMBL2163532 | — | Ki | > | 100.0 | nM | - |