Assay Detail
Functional
CHEMBL2167688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP production
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.98 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165801 | — | — | 1 | 9.30 |
| CHEMBL2165802 | — | — | 1 | 8.74 |
| CHEMBL2165807 | — | — | 1 | 8.62 |
| CHEMBL2165800 | — | — | 1 | 8.60 |
| CHEMBL2165808 | — | — | 1 | 8.28 |
| CHEMBL2165799 | — | — | 1 | 8.22 |
| CHEMBL2165804 | — | — | 1 | 8.05 |
| CHEMBL1087189 | — | — | 1 | 7.77 |
| CHEMBL2165803 | — | — | 1 | 7.53 |
| CHEMBL2165805 | — | — | 1 | 7.43 |
| CHEMBL1095488 | — | — | 1 | 7.32 |
| CHEMBL1087185 | — | — | 1 | 7.23 |
| CHEMBL2165806 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165801 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2165802 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2165807 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL2165800 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2165808 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL2165799 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2165804 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1087189 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2165803 | — | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL2165805 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL1095488 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL1087185 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL2165806 | — | Ki | = | 223.0 | nM | 6.65 |