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Compound Detail

CHEMBL2165801

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Nc1nc(-c2ccccc2)c2c(n1)-c1cc(Cc3cnccc3Cl)ccc1C2=O

Basic Information

ChEMBL ID CHEMBL2165801
Phase Preclinical
Structure Type MOL
InChI Key BLTKTCQOSSTUDS-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

398.9
MW (Da)
4.58
ALogP
5
HBA
1
HBD
81.8
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H15ClN4O
MW 398.85
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness -0.41

Activity Summary

Ki 2 meas. best 10.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 10.0 10.0 0.1 1
Adenosine receptor A1
CHEMBL226
Ki 9.3 9.3 0.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22239465 10.1021/jm201640m Mus musculus 1
22239465 10.1021/jm201640m Adenosine receptor A1 1
22239465 10.1021/jm201640m Adenosine receptor A2a 1

Data from ChEMBL 36 via Core Engine